LIQUID PHASE ORGANIC SYNTHESIZER, “CHEMIST PLAZA” Large Capacity CPG-2000

manufacturered by LIQUID PHASE ORGANIC SYNTHESIZER, “CHEMIST PLAZA” Large Capacity CPG-2000 Small Capacity CP-1000

Introduction To bond organic compounds with other substances or organic compounds with organic compounds Examples of organic compounds → Organic solvents, plastics, rubbers, drugs, dyes, perfumes, etc What are organic compounds? → Compounds that are mainly carbon, with most compounds consisting of carbon and hydrogen Goals of Organic Synthesis ①To create a new substance To develop a new material → Resin, fibers, dyes, etc To develop new chemical substances → New drugs, perfumes, high performance substances ②To make existing substances at low cost Synthesis of natural products → Manufacture expensive natural products industrially → Uniform quality ③Other research goals Specific Example Mass production of active ingredients of natural substances An active ingredient that has pain relieving effects was found to exist in willow branches. ↓ It can not be mass produced from natural products (Mass amounts of willow braches would be necessary.) ↓ The main substances are synthetically arranged by chemical synthesis (organic synthesis) ↓ Enables the mass production/manufacturing of aspirin (acetylsalicylic acid: pain reliever/fever reducer) ↓ Enables sales as medication Research procedures of organic synthesis Determine the new substance according to goals. (Determine the structures of substances that have the characteristics that are in accordance to goals from documents.) ↓ Determine how to synthesize. (Determine the synthesizing method for production and start development.) ↓ Heat, cool, stirring, etc. Evaluate product. (Determine if product coincides with original goal if it does not, re-determine synthesis methods.) ↓ Determine the manufacturing method, determination of (scaling up) (Determination of methods and conditions where the compounds can be mass produced in the most cost effective way.) ↓ Goes to market as a product...

Main Features of the CHEMIST PLAZA CPG-2000（large capacity type） ■ For determination of large capacity reaction! ● 4 reaction containers with the ability to setup each temperature and stirring individually. ● Possible to set temperature, stirring, time programs ■ Target markets ◇ Universities, department of pharmacy, chemistry departments ◇ Research, development, composite departments of pharmaceuticals and medicines ◇ Development of new materials in cosmetics, perfumes When the synthesis scale is too small with the CP-100 ◇ When temperature, stirring, and temperature rising programs need to be set up for determination of reaction conditions CP-1000 (small capacity type) ■ For determination of small capacity reaction! ● 5 reaction containers with ability the to set temperature and stirring up individually ■ Target markets ◇ Universities, department of pharmacy, chemistry departments ◇ Research, development, composite departments of pharmaceuticalsand medicines ◇ Development of new materials in cosmetics, perfumes If you need to reduce your operation Space and Time, the Chemist Plaza can be used in place of Magnetic stirrer, Heaters, Flasks(2 or 3necks), and Condensers. →

CPG-2000 For Determination of Conditions for Large Capacity Reactions!! The Chemist Plaza CPG-2000 series are devices well suited for large capacity organic synthesis such as development of new reaction,and new catalysts, synthesis of intermediate products, and when scaling-up small capacity samples to large capacity samples. To efficiently determine reaction conditions, temperature, stirring (number of rotations), and program (temperature, stirring, time) of the 4 blocks on the main body can be set individually. Individual Manual, Program Operation for 4 Specimen (Possible to setup temperature, stirring speed, time) Individual Program Functions, Link Functions (Possible to setup temperature, stirring speed, time) 4 Varieties of Reaction Containers 9 varieties of program setups possible per block. 2 varieties of standard reaction containers; the 100mL Loaded with a link function that connects each type (CPG-2110) and 200mL type (CPG-2120). program. Optionally, two mouth types are available. Maximum 81 steps are programmable per program. Please contact us for other special order support. Example: 1 Program (3step) Step1 Step2 Step3 Temp. Stop 30min. 10min. Start Time Individual Temperature Adjustment from -30~200℃ (two mouth) (two mouth) Each of the 4 heating blocks have auto-tuning function loaded in the so that temperatures can be Container Units, Container Holders individually set (-30~200℃), enabling highly precise Exchanging just the container holder or reaction heating and cooling. container enables different reaction experiments * 1 A cooling water circulation device is necessary to be performed on each of the heating blocks. if the temperature is to be adjusted below room Aluminum block holder, Return current unit, temperature. Container holder Strong Individual Agitation of 50 to 2000rpm Cooling Catridge When a low temperature circulation tank is connected, return current and low temperature reaction can be preformed. The cooling cartridge can be inserted from Aluminum Reflux unit Container both the right and left side of the main body block holder holder and the connection nozzle will turn 360 degrees. Reagent Adder The hose will not The reagent adder is a bend and can be SPC15 joint. Mounting arranged in any the included silicon direction. septum and the reagentscan also be added with a syringe. Septum SPC15 jointControl Panel Display TIMER key Current temperature of the heating Use to set the time in manual mode and block, number of rotations, program, program mode. and step number is displayed according to the conditions. START/STOP keyThis is the ON/OFF switch for the heating MODE key program of each of the heating blocks. Use to convert to and from manual mode and program mode. Revolution Adjustment Volume SET key Use to set the number of rotations of the stirrer. Use to edit the program in program mode

Specifications Models in sets Synthesizer Main Body Synthesize Scale Reaction Type, No. of Units Atmospheric pressure: glass containers x 4 Vessel Dimensions (mm) Dimension of Stirring Bar (mm) Max. dia. approx. 13mm x total length 25mm, Oval edge type Stirrer Dimensions (mm) pcs Setting Range 4 individual temperature adjustment Temperature Setting Accuracy Setup/Display Sheet key entry/Digital LED Display Setting Range 50~2000rpm, 4 individual stirrers Revolutions Stirring Method Ferromagnetic Stirrer Method Setup/Display Volume entry (During program control: digital up down setup) Digital LED Display Program Program Number 9 programs (individually separate blocks: 4locations)/9 steps (per program) Functions Program Link Func. 9 step/1 program x 9 programs (maximum program links of 81 steps possible:4 locations)Setup Contents Temperature, number of revolutions, time (constant temperature, rising temperature program possible), ON/OFF timer Gas Displacement Vacuuming/Inert gas induction possible, Connection port outside diameter φ8mm Reflux Reflux via cleaning cartridge (cooling plate can be attached and removed from both left and right sides) *1 Low Temperature Reaction Reflux via cleaning cartridge (cooling plate can be attached and removed from both left and right sides) *1 Reagent Addition Method Pipit, syringe, dropping funnel (SPC15) possible to add either under inert conditions Reaction Observation Observation possible from slit in aluminum block Safety Measures Polycarbonate cover, drip receiving tray, over heating/over cooling warnings (able to set individually) Wetted Material Glass Cooling Water Connection Port Outside diameter φ10mm, φ12.7mm 2stange hose port Analog Output Operational Ambient Temperaure Dimensions Weight Power Supply Ordering Code No. It is necessary to connect a cooling water circulation device if the temperature is adjusted below room temperature or return current is to be performed CPG Series Standard Component Order No. Description Q'ty Necessary number Necessary number Synthesizer Main Body Cooling cartridge 4pcs Heating block adapter Reaction container stand Stirrer, oval edge model Refrux unit Container holder stand Reagent addition part Reaction container Reaction container Two way valve set Joint clamp for taper Septum Optional Parts Order No. Description Q'ty Cooling cartridge 2pcs SPC two mouth reaction container SPC two mouth reaction container SPC flat plug for SPC15 SPC flat plug for SPC29 Test tube adapter set Test tube adapter set Test tube adapter set

CP-1000 For Determination of Conditions for Small Capacity Reactions!! Temperatures and stiiring of the 5 reaction containers of the CP-1000 series can be set individually, which enables an efficient determination of 5 types of reaction conditions simultaneously. It is equipped with heating, cooling, return current, and gas flow functions andcan also speedily perform concentrations after reaction. Individual Temperature Adjustment from -20~160℃ The built in auto-tuning function enables high precision heating and cooling. 6 varieties of Reaction Containers! A total varieties; the test tube type (2 varieties), vial type (variety), and the SPC test tube type (2 varieties) 222mm to choose from. 330mm An Ultra Compact Body needs less than the Surface Area of A3 Size Paper for Installation!! Width 330mm X Depth 222mm Strong Indivisdual Agitation of 100 to 2000rpm A Ferromagnetic stirrer is used for strong agitation. Complete Safety Functions Container Unit, Container Holder The safety cover prevents casualties from accidental The entire rack of the container unit can be removed dispersion of glass test tubes. from the main body. Constructed so that the power is not supplied if the Each of the container blocks are independent of one safety cover is not on. another, enabling the use of different containers. Over Heating/Over Cooling Warnings When the heating block reaches a certain temperature in relation to the set temperature, a warning buzzer will sound and the individual displays will show an error message. Further, each heating block can be set to its own high-low limit. Cooling Cartridge When a low temperature Prevent Condensation circulation tank is connected, Send dry air without using nitrogen gas and prevent return current and low condensation within the device. temperature reaction can be preformed. The connection nozzle will t urn 360 degrees, and can be installed in any location. Gas inlet port * The silica gel is sold separately.

Line-Up Name in Setting φ15x105H Test Tube set φ15x150H Test Tube set φ30x200H Test Tube set Type of Vessel Test Tube with Lip Test Tube with Lip Test Tube with Lip Size of Vessel φ15x105Hmm φ15x150Hmm φ30x200Hmm Synthesize Capacity 7mL (Max.) 7mL (Max.) 30mL (Max.) Ordering Code 054300-1010 054300-1020 084300-1030 φ15×105H Test Tube set φ15×150H Test Tube set φ30×200H Test Tube set Name in Setting SPC15 Test Tube set SPC29 Test Tube set Vial Tube set Type of Vessel SPC Test Tube SPC Test Tube Vial Tube Size of Vessel φ15x170Hmm φ30x190Hmm φ30x65Hmm Synthesize Capacity 7mL (Max.) 30mL (Max.) 28mL (Max.) Ordering Code 054300-1040 054300-1050 084300-1060 SPC15 Test Tube set SPC29 Test Tube set Vial Tube set Specifications Model CP-1000 Installed Reaction Vessel 1 to 5 Tubes Temperature Setting Range -20 to 160℃, Individual setting Setting / Display Sheet key entry/ Digital LED display with back-lit Setting Range 100 to 2000rpm, Individual setting Agitation Setting / Display Volume entry / Digital LED display with back-lit Stirring Type Ferromagnetic stirrer Reflux Method Reflux by cooling cartridge *1 Overall Dimensions 330W x 222D x 325Hmm Weight Approx. 15kg Ordering Code No. 054300-1000 Temperature of 5 heating blocks can setup individualy.

Parts for CP-1000 (Includes optional items) Ordering Code No. Description Q’ty ① 054310-1601A Test tube φ15 x 105mm 100 Test tube ② 054310-1602A Test tube φ15 x 150mm 50 ③φ30×200mm ③ 054310-1603A Test tube φ30 x 200mm 25 ④ 054310-1606A Vial tube 28mL 50 ①φ15 x 105mm ⑤ 054310-1608A SPC Test tube φ15 x 170mm 10 ⑥ 054310-1609A SPC Test tube φ30 x 190mm 10 ⑦ 054310-4410 PTFE adapter (with taper) for φ15 test tube 1 ⑧ 054310-4420 PTFE adapter (with taper) for φ30 test tube 1 ⑨ 054310-4430 PTFE adapter (with taper) for vial tube 1 ⑩ 054310-1201A Stirrer cross shape forφ15 test tube 10 054310-1202A Stirrer cross shape forφ30 test tube 10 054310-1204A Stirrer triangle shape for vial tube 28mL 10 ④Vial tube ⑪ 054310-1207A Stirrer cross shape forφ30 test tube L25 10 ②φ15×150mm ⑫ 054310-4210 Reflux unit for φ15 x 105mm test tube 1 ⑬ 054310-4220 Reflux unit for φ15 x150mm, SPC φ15 test tube 1 SPC Test tube ⑭ 054310-4230 Reflux unit for φ30 test tube, Vial tube 1 ⑮ 054310-4310 Heat block adaptor for φ15 tube 1 ⑤φ15×170H ⑯ 054310-4110 Cooling cartridge 1 ⑰ 030300-1529 SPC adaptor SPC15 - SPC29 1 ⑱ 054310-4510 Three-way cock SPC15 1 054310-1804A Septum 10 ⑲ 030300-2915 SPC adaptor SPC29 - SPC15 1 007020-2915 T S joint adaptor 29/40 - 15/25 1 030730-15150 Dimroth condenser SPC15 1 030230-1525 Separatory funnel, SOC joint 1 054330-5100 Liebig condenser SPC15, GL14 1 ⑥φ30×190H 054330-5200 Half-moon shaped funnel SPC15 1 054330-5300 Funnel with stop cock, 50mL 1 Stirrer cross shape PTFE adapter (with taper) ⑧for φ30 test tube ⑩forφ15 ⑪forφ30 ⑦for φ15 test tube Reflux unit ⑨for vial tube ⑫for φ15 x 105mm ⑬φ15 x150mm, SPC φ15 ⑭for φ30 test tube, Vial tube ⑰SPC adaptor ⑲SPC adaptor SPC15 - SPC29 ⑮Heat block adaptor ⑯Cooling cartridge ⑱Three-way cock SPC15 1-1-62, Nakane Soka-City, Saitama, Japan TEL:+81-48-933-1574　FAX:+81-48-933-1591 E-mail:overseas@sibata.co.jp http://www.sibata.co.jp/english/ 201405K